劉博侖 教授                                                                                

聯絡電話：07-3121101轉2801 

E-Mail：kisa@kmu.edu.tw

office hour：每週二、四 15：00～17：00

職稱

教授

學歷/經歷

國立陽明大學生理學研究所博士

國立陽明大學解剖暨細胞生物研究所碩士

國立台北護理學院學士

專長領域         

解剖學

呼吸生理學

動脈硬化防治

細胞分子生理學

教學科目

生理學

解剖學

基礎心電圖

分子生物學

組織學概論

心肺解剖生理學

心肺血管疾病特論

呼吸治療研究導論

細胞生理學研究技術

五年著作目錄

1.        Chong-Chao Hsieh, Hsuan-Fu Kuo, Hsiao-Hsuan Wang, Mo Da-Sang Hua, I-Line Chen, Jia-Ling Lin, Yi-Ching Lo, Zi-Jing Lin, Yung-Hsiang Chen, Yur-Ren Kuo, Chih-Hsin Hsu, Po-Len Liu*. (2025 Sep). Plumbagin improves pulmonary vascular remodeling in PAH via miR-21-5p/MMP/TIMP regulation, with diagnostic implications for cardiac function. Biomed Pharmacother. 192:118604. (本人為通訊作者)

2.        Po-Len Liu, Zhi-Wei Xu, Wen-Shuo Kuo, Chih-Hsin Hsu, Yu-Ru Liu, Min-Zhen Lu, Sheng-Bo Lai, Jui-Chi Chang, Hsiao-Hsuan Wang, Chia-Yuan Chang. (2025 Jul). Pulmonary artery hypertension-induced vascular structure analysis using label-free fluorescence lifetime imaging. Opt Experss. 28;33(15):31935-31948.(本人為第一作者)

3.        Meng-HsuanCheng, Hsiao-HsuanWang, MoDa-SangHua, Hsuan-FuKuo, Zi-JingLin, Chong-ChaoHsieh, Chih-HsinHsu, Chia-YangLi, Shu-ChiWang, Yung-HsiangChen, Szu-HuiWu, Wei-LunLiu, Po-Len Liu*. (2025 Jun). Magnolol facilitates mitochondrial-peroxisome dysfunction and induces oxeiptosis in lung cancer cells following transfer via tunneling nanotubes. Biomed Pharmacother. 187:118126. (本人為通訊作者)

4.        Meng-Hsuan Cheng, Hsuan-Fu Kuo, Chia-Yuan Chang, Jui-Chi Chang, I-Fan Liu, Chong-Chao Hsieh, Chih-Hsin Hsu, Chia-Yang Li, Shu-Chi Wang, Yung-Hsiang Chen, Chuang-Rung Chang, Tsung-Ying Lee, Yu-Ru Liu, Chi-Yuan Huang, Szu-Hui Wu, Wei-Lun Liu, Po-Len Liu*. (2024 May). Curcumin regulates pulmonary extracellular matrix remodeling and mitochondrial function to attenuate pulmonary fibrosis by regulating the miR-29a-3p/DNMT3A axis. Biomed Pharmacother. 174:116572. (本人為通訊作者)

5.        Ting-En Chen, Jung Lo, Shu-Pin Huang, Kun-Che Chang, Po-Len Liu, Hsin-En Wu, Yuan-Ru Chen, Yo-Chen Chang, Ching-Chih Liu, Po-Yen Lee, Yu-Hung Lai, Pei-Chang Wu, Shu-Chi Wang, Chia-Yang Li*. (2024 Oct). Glaucine inhibits hypoxia-induced angiogenesis and attenuates LPS-induced inflammation in human retinal pigment epithelial ARPE-19 cells. Eur J Pharmacol. 2024 Oct 15:981:176883.

6.        Hsin-En Wu, Chia-Cheng Su, Shu-Chi Wang, Po-Len Liu, Wei-Chung Cheng, Hsin-Chih Yeh, Chih-Pin Chuu, Jen-Kun Chen, Bo-Ying Bao, Cheng Hsueh Lee, Chien-Chih Ke, Yuan-Ru Chen, Yun-Hsin Yu, Shu-Pin Huang, and Chia-Yang Li*. (2023 Apr). Anticancer Effects of Morusin in Prostate Cancer via Inhibition of Akt/mTOR Signaling Pathway. Am J Chin Med. 51(4):1019-1039.

7.        Yu-Hung Lai, Wei-Lun Liu, Tsung-Ying Lee, Chung-Wen Kuo, Yu-Ru Liu, Chi-Yuan Huang, Yung-Hsiang Chen, I-Ling Chen, Szu-Hui Wu, Shu-Chi Wangi, Po-Yen Lee, Ching-Chih Liu, Jung Lo, Yo-Chen Chang, Hsuan-Fu Kuo, Chong-Chao Hsieh, Chia-Yang Li, and Po-Len Liu*. (2023 Feb). Magnolol regulates miR-200c-3p to inhibit EMT and retinoblastoma progression by modulating the ZEB1/E-cadherin axis in vitro and in vivo. Phytomedicine. 110:154597. (本人為通訊作者)

8.        Fan Liu, Tzu-Chieh Lin, Shu-Chi Wang, Chia-Hung Yen, Chia-Yang Li, Hsuan-Fu Kuo, Chong-Chao Hsieh, Chia-Yuan Chang, Chuang-Rung Chang, Yung-Hsiang Chen, Yu-Ru Liu, Tsung-Ying Lee, Chi-Yuan Huang, Chih-Hsin Hsu*, Shing-Jong Lin* and Po-Len Liu*. (2023 Mar). Long-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling involving caveolae and caveolin-1 expression. Biol Direct. 18(1):9. (本人為通訊作者)

9.        Yuan-Ru Chen, Shu-Chi Wang, Shu-Pin Huang, Chia-Cheng Su, Po-Len Liu, Wei-Chung Cheng, Chih-Pin Chuu, Jen-Kun Chen, Bo-Ying Bao, Cheng Hsueh Lee, Chien-Chih Ke, Hsin-En Wu, Hao-Han Chang, Hsin-Chih Yeh*, and Chia-Yang Li*. (2022 Dec). Protodioscin inhibits bladder cancer cell migration and growth, and promotes apoptosis through activating JNK and p38 signaling pathways. Biomed Pharmacother. 156:113929.

10.   Jung Lo, Ching-Chih Liu, Yueh-Shan Li, Po-Yen Lee, Po-Len Liu, Pei-Chang Wu, Tzu-Chieh Lin, Chi-Shuo Chen, Chien-Chih Chiu, Yu-Hung Lai, Yo-Chen Chang, Hsin-En Wu, Yuan-Ru Chen, Yu-Kai Huang, Shu-Pin Huang, Shu-Chi Wang, and Chia-Yang Li*. (2022 Sep). Punicalagin Attenuates LPS-Induced Inflammation and ROS Production in Microglia by Inhibiting the MAPK/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation. J Inflamm Res. 15:5347-5359.

11.   Szu-Ju Chen, Sunderiya Dalanbaatar, Huey-Yi Chen, Shih-Jing Wang, Wei-Yong Lin, Po-Len Liu, Ming-Yen Tsai, Der-Cherng Chen, Yung-Hsiang Chen, and Wen-Chi Chen. (2022 Aug). Astragalus membranaceus Extract Prevents Calcium Oxalate Crystallization and Extends Lifespan in a Drosophila Urolithiasis Model. Life (Basel). 12(8):1250.

12.   Hsin-Chih Yeh, Chia-Cheng Su, Yen-Hsuan Wu, Cheng Hsueh Lee, Bo-Ying Bao, Wei-Chung Cheng, Shu-Chi Wang, Po-Len Liu, Chien-Chih Chiu, Chih-Pin Chuu , Chien-Chih Ke, Hsin-En Wu, Yuan-Ru Chen, Wei-Ju Chung, Shu-Pin Huang, and Chia-Yang Li*. (2022 May). Novel insights into the anti-cancer effects of 3-bromopyruvic acid against castration-resistant prostate cancer. Eur J Pharmacol. 923:174929.

13.   Chen Chen, Shu-Chi Wang, Yi-Ting Chen, Hsin-Han Tseng, Po-Len Liu, Tzu-Chieh Lin, Hsin-En Wu, Yuan-Ru Chen, Yu-Hsin Tseng, Jong-Hau Hsu, Zen-Kong Dai, Jau-Ling Suen, and Chia-Yang Li*. (2021 Oct). Corylin Ameliorates LPS-Induced Acute Lung Injury via Suppressing the MAPKs and IL-6/STAT3 Signaling Pathways. Pharmaceuticals (Basel). 14(10):1046.

14.   Hsuan-Fu Kuo, I-Fan Liu, Chia-Yang Li, Chien-Sung Tsai, Yung-Hsiang Chen, Wei-Shiung Lian, Tzu-Chieh Lin, Yu-Ru Liu, Tsung-Ying Lee, Chi-Yuan Huang, Chong-Chao Hsieh, Chih-Hsin Hsu, Feng-Yen Lin, and Po-Len Liu*. (2021, Oct). Endocardial Endothelial Dysfunction and Unknown Polymorphic Composite Accumulation in Heart Failure. Biomedicines. 9(10):1465. (本人為通訊作者)

15.   Chih-Hsin Hsu, I-Fan Liu, Hsuan-Fu Kuo, Chia-Yang Li, Wei-Shiung Lian, ChiaYuan Chang, Yung-Hsiang Chen, Wei-Lun Liu, Chi-Yu Lu , Yu-Ru Liu, Tzu-Chieh Lin, Tsung-Ying Lee, Chi-Yuan Huang, Chong-Chao Hsieh*, and Po-Len Liu*. (2021, Sep). miR-29a-3p/ HBS2 Axis Regulates PAH-induced Cardiac Fibrosis. International Journal of Molecular Sciences. 22(19), 10574. (本人為通訊作者)

16.   Wei-Lun Liu, Chia-Yang Li, Wei-Chung Cheng, Chia-Yuan Chang, Yung-Hsiang Chen, Chi-Yu Lu, Shu-Chi Wang, Yu-Ru Liu, Meng-Hsuan Cheng, Inn-Wen Chong, and Po-Len Liu*. (2021, Mar). High Mobility Group Box 1 Promotes Lung Cancer Cell Migration and Motility via Regulation of Dynamin-Related Protein 1. Int J Mol Sci. 22(7):3628. (本人為通訊作者)

17.   Yu-Hung Lai, Po-Yen Lee, Chi-Yu Lu, Yu-Ru Liu, Shu-Chi Wang, Ching-Chih Liu, Yo-Chen Chang, Yung-Hsiang Chen, Chia-Cheng Su, Chia-Yang Li, and Po-Len Liu*. (2020, Jan). Thrombospondin 1-induced exosomal proteins attenuate hypoxia-induced paraptosis in corneal epithelial cells and promote wound healing. FASEB J. 35(1):e21200. (本人為通訊作者)

18.   Yung-Hsiang Chen, Wen-Chi Chen, Kao-Sung Tsai, Po-Len Liu, Ming-Yen Tsai, Shih-Chieh Yu, and Huey-Yi Chen. (2020, Jul). Efficacy of Frankincense and Myrrha in Treatment of Acute Interstitial Cystitis/Painful Bladder Syndrome. Chin J Integr Med. 26 (7):519-526.

19.   Yung-Hsiang Chen, Wen-Chi Chen, Po-Len Liu, and Huey-Yi Chen*. (2020, Mar). Astragalus polysaccharides and astragaloside IV ameliorates cyclophosphamideinduced mouse model of overactive bladder. Taiwan J Obstet Gynecol. 59(2):248-255.

20.   Chong-Chao Hsieh, Chia-Yang Li, Chih-Hsin Hsu, Hsiu-Lin Chen, Yung-Hsiang Chen, Yu-Peng Liu, Yu-Ru Liu, Hsuan-Fu Kuo*, and Po-Len Liu*. (2019, Oct). Mitochondrial protection by simvastatin against angiotensin II-mediated heart failure. British Journal of Pharmacology.176(19):3791-3804. MOST 104-2314-B-037-087. (本人為通訊作者)

21.   Hsuan-Fu Kuo, Chong-Chao Hsieh, Shu-Chi Wang, Chia-Yuan Chang, Chih-Hsin Hung, Po-Lin Kuo, Yu-Ru Liu, Chia-Yang, Po-Len Liu*. (2019, Jun). Simvastatin Attenuates Cardiac Fibrosis via Regulation of Cardiomyocyte- Derived Exosome Secretion. J Clin Med. 8(6):794. MOST 104-2314-B-037-087. (本人為通訊作者)

22.   Rong-Hsing Chen, Kee-Ming Man, Huey-Yi Chen, Szu-Ju Chen, Wei-Shan Chen, Po-Len Liu, Yung-Hsiang Chen,* and Wen-Chi Chen*. (2019, May). Thyroid Diseases Increased the Risk of Type 2 Diabetes Mellitus: A Nation-wide Cohort Study. Medicine (Baltimore). 98(20): e15631. 

23.   Wen-Tsung Huang, Inn-Wen Chong, Hsiu-Lin Chen, Chia-Yang Li, Chong-Chao Hsieh, Hsuan-Fu Kuo, Chia-Yuan Chang, Yung-Hsiang Chen, Yu-Peng Liu, Chi-Yu Lu, Yu-Ru Liu, Po-Len Liu*. (2019, Feb). Pigment epithelium-derived factor inhibits lung cancer migration and invasion by upregulating exosomal thrombospondin 1. Cancer Lett. 442:287-298. MOST 104-2314-B-037-087. (本人為通訊作者).

近三年研究計畫

專利

1.      美國: DR20：A NOVEL ANTI-FIBROTIC, ANTI-CANCER, ANTI-PAH THERAPIES DRUG(63/716, 785)，劉博侖、林韋佑、郭炫孚、鄭孟軒

2.      美國: 用於促進皮膚細胞增生及／或遷移的組成物、生薑萃取物及其醫藥組成物(8,772,347)，王惠民、陳中一、邱建志、周怡廷、劉博侖

3.      中華民國: 具雙影像追蹤探針之高分子奈米載體及其製備方法(I530296)，王志光、潘力誠、李之昀、林宏哲、林哲緯、劉博侖、史秉修

4.      中華民國: 用於促進皮膚細胞增生及/或遷移的組成物,生薑促取物及醫藥組成物(I446919)，王惠民、陳中一、邱建志、周怡廷、劉博侖