伯倫          

 

劉博侖 老師                                                                                

聯絡電話:07-31211012801 

E-Mailkisa@kmu.edu.tw

office hour:每週二、四 15001700

職稱

教授

學歷/經歷

國立陽明大學生理學研究所博士

國立陽明大學解剖暨細胞生物研究所碩士

國立台北護理學院學士

專長領域         

解剖學

呼吸生理學

動脈硬化防治

細胞分子生理學

教學科目

生理學

解剖學

基礎心電圖

分子生物學

組織學概論

心肺解剖生理學

心肺血管疾病特論

呼吸治療研究導論

細胞生理學研究技術

期刊論文:

 

2019

1

Mitochondrial protection by simvastatin against angiotensin II-mediated heart failure

Chong-Chao Hsieh, Chia-Yang Li, Chih-Hsin Hsu, Hsiu-Lin Chen, Yung-Hsiang Chen, Yu-Peng Liu, Yu-Ru Liu, Hsuan-Fu Kuo*, and Po-Len Liu*

British Journal of Pharmacology. (Accepted) 2018-BJP-0575-RP.R4  IF: 6.81; Rank: 12/261=4.597%    PHARMACOLOGY & PHARMACY

2.

Simvastatin Attenuates Cardiac Fibrosisvia Regulation of Cardiomyocyte-Derived Exosome Secretion

 Hsuan-Fu Kuo, Chong-Chao Hsieh, Shu-Chi Wang, Chia-Yuan Chang, Chih-Hsin Hung, Po-Lin Kuo, Yu-Ru Liu, Chia-Yang Li,* and Po-Len Liu*

 Journal of Clinical Medicine. 2019, 8, 794; doi:10.3390/jcm8060794   IF: 5.583; Rank: 15/155=9.677%    MEDICINE, GENERAL & INTERNAL

3

Thyroid Diseases Increased the Risk of Type 2 Diabetes Mellitus: A Nation-wide Cohort Study.

Rong-Hsing Chen, Kee-Ming Man, Huey-Yi Chen, Szu-Ju Chen, Wei-Shan Chen, Po-Len Liu, Yung-Hsiang Chen,* Wen-Chi Chen*

Medicine (Baltimore). 2019 May;98(20):e15631.  IF: 2.028;Rank: 56/155=36.12%    MEDICINE, GENERAL & INTERNAL

4

AICAR induces apoptosis and inhibits migration and invasion in prostate cancer cells through an AMPK/mTOR-dependent pathway

Chia-Cheng Su, Kun-Lin Hsieh, Po-Len Liu, Hsin-Chih Yeh, Shu-Pin Huang, Shih-Hua Fang, Wei-Chung Cheng, Kuan-Hua Huang, Fang-Yen Chiu, I-Ling Lin, Ming-Yii Huang *, Chia-Yang Li *

International Journal of Molecular Sciences2019 Apr 3;20(7). pii: E1647.  IF: 3.687;Rank: 90/293=30.07%      BIOCHEMISTRY&MOLECULAR BIOLOGY

5

The sodium-glucose co-transporter 2 inhibitor empagliflozin attenuates cardiac fibrosis and improves ventricular hemodynamics in hypertensive heart failure rats.

Lee HC, Shiou YL, Jhuo SJ, Chang CY, Liu PL, Jhuang WJ, Dai ZK, Chen WY, Chen YF, Lee AS*.

Cardiovascular Diabetology. 2019 Apr 1;18(1):45.   doi: 10.1186/s12933-019-0849-6.  IF: 5.235;

6

Discovery of 2-aroyl-3-arylquinoline derivatives as potential anti-inflammatory agents through inhibiting LPS-induced inflammatory responses in macrophages

Cheng-Yao Yang, Yung-Li Hung, Kai-Wei Tang, Shu-Chi Wang, Chih-Hua Tseng, Cherng-Chyi Tzeng, Po-Len Liu, Chia-Yang Li *, Yeh-Long Chen *

Molecules. 2019 Mar 23;24(6).  IF: 3.098;Rank: 68/171=39.76%   CHEMISTRY, MULTIDISCIPLINARY

7

Pigment epithelium-derived factor inhibits lung cancer migration and invasion by upregulating exosomal thrombospondin 1.

Huang WT, Chong IW, Chen HL, Li CY, Hsieh CC, Kuo HF, Chang CY, Chen YH, Liu YP, Lu CY, Liu YR, Liu PL*.

Cancer Letters. 2019 Feb 1;442:287-298.   doi: 10.1016/j.canlet.2018.10.031.  IF: 6.421;Rank: 69/223=13%      ONCOLOGY

2018

1

Pigment epithelium-derived factor inhibits lung cancer progression by upregulating exosomal thrombospondin 1

Chong IW# and Huang WT #, Chen HL, Lee CY, Hsieh CC, Kuo HF, Chang CY, Chen YH, Liu YP, Lu Chi-Yu, Liu YR and Liu PL*

Cancer Letters; (CAN-D-18-02008R1) IF: 6.491; Rank: 28/222=11.61% (ACCEPT-1071025)

2

RNA-seq transcriptome analysis of breast cancer cell lines under shikonin treatment.

Lin KH, Huang MY, Cheng WC, Wang SC, Fang SH, Tu HP, Su CC, Hung YL, Liu PL, Chen CS, Wang YT, Li CY.

Sci Rep. 2018 Feb 8;8(1):2672. IF: 4.122; Rank:12/64=18.75%

3.

Corylin inhibits LPS-induced inflammatory response and attenuates the activation of NLRP3 inflammasome in microglia
Ming-Yii Huang; Chia-En Tu; Shu-Chi Wang; Yung-Li Hung; Chia-Cheng Su; Shih-Hua Fang,; Chi-Shuo Chen; Po-Len Liu; Wei-Chung Cheng; Yu-Wei Huang; Chia-Yang Li*.

BMC Complement Altern Med. 2018 Aug 15;18(1):221. IF: 2.109; Rank:8/39=29.62%

4

Simvastatin Attenuates Cardiac Fibrosis via Regulation of Cardiomyocyte-Derived Exosome Secretion

Hsuan-Fu Kuo, Chong-Chao Hsieh, Chih-Hsin Hsu, Chia-Yang Li, Hsiu-Lin Chen, Chia-Yuan Chang, Bin Huang, Yu-Ru Liu, Hsiang-Chun Lee and Po-Len Liu* (under review)

Sci Rep. 2018 (SREP-18-35098-T); IF: 4.122; Rank: 12/64=18.75%

5

Mitochondria protection by statin against angiotensin II-mediated heart failure

Chong-Chao Hsieh, Chih-Hsin Hsu, Hsiu-Lin Chen, Chia-Yang Li, Yung-Hsiang Chen, Yu-Ru Liu, Hsuan-Fu Kuo* and Po-Len Liu*

British Journal of Pharmacology; ( 2018-BJP-0575-RP); IF: 6.81; Rank:12/261=4.59% (Revised)

6

Thyroid Diseases Increased the Risk of Type 2 Diabetes Mellitus: A Nation-wide Cohort Study.

Rong-Hsing Chen, Kee-Ming Man, Huey-Yi Chen, Szu-Ju Chen, Wei-Shan Chen, Po-Len Liu, Yung-Hsiang Chen,1,2,5,* Wen-Chi Chen* (under review)

Clinical Endocrinology (CEN-2018-000944); IF: 3.077; Rank: 70/143=48.95%

2017

1

miR-200c inhibits epithelial-mesenchymal transition and metastasis of lung cancer by targeting HMGB1

Po-Len Liu, Wei-Lun Liu, Jia-Ming Chang, Yung-Hsiang Chen, Yu-Peng Liu, Hsuan-Fu Kuo, Chong-Chao Hsieh, Yu-Sian Ding, Wei-Wei Chen and Inn-Wen Chong*

PLoS One. 2017 Jul 20;12(7):e0180844.

MULTIDISCIPLINARY SCIENCES   IF:2.806  R/K: 15/64=23.43%

2

Curcumin inhibits LIN28A-regulated MMP2/9 activation and suppresses lung cancer metastasis  

Via upregulation of miR-98

Wei-Lun Liu, Jia-Ming Chang, Inn-Wen Chong, Yi-Li Hung, Yung-Hsiang Chen, Wen-Tsung Huang, Hsuan-Fu Kuo, Chong-Chao Hsieh, Po-Len Liu *

Molecules 2017 Jun 3;22(6). 

SCI; Original articles

CHEMISTRY, ORGANIC         IF: 2.861    R/K: 17/59=28.81%

3

Corylin protects LPS-induced sepsis and attenuates LPS-induced inflammatory response.

Hung YL, Fang SH, Wang SC, Cheng WC, Liu PL, Su CC, Chen CS, Huang MY, Hua KF, Shen KH, Wang YT, Suzuki K, Li CY*.

Sci Rep. 2017 Apr 11;7:46299. doi: 10.1038/srep46299.

SCI; Original articles

MULTIDISCIPLINARY SCIENCES         IF: 4.259    R/K: 10/64=15.62%

2016

1

Postnatal Changes in Tibial Bone Speed of Sound of Preterm and Term Infants during Infancy.

Hsiu-Lin Chen, Wei-Te Lee , Pei-Lun Lee, Po-Len Liu, Rei-Cheng Yang*

PLoS One. 2016 Nov 10;11(11):e0166434.

MULTIDISCIPLINARY SCIENCES   IF:2.806     R/K: 15/64=23.43%

2

Peroxisome Proliferator-activated Receptor α Inhibits Endothelin-1-caused Cardiomyocyte Hypertrophy by Preventing Nuclear Translocation of Nuclear Factor-κB and Adiponectin.

Hsu-Lung Jen, Po-Len Liu, Yung-Hsiang Chen, Wei-Hsian Yin, Jaw-Wen Chen and Shing Jong Lin*

Mediators of Inflammation. 2016; 2016:5609121.

SCI; Original articles

IMMUNOLOGY   IF: 3.232  R/K: 94/189=49.73%

 3.

Pigment Epithelium-Derived Factor Mediates Autophagy and Apoptosis in Myocardial Hypoxia/

Reoxygenation Injury

Hsuan-Fu Kuo, Po-Len Liu, Inn-Wen Chong, Yu-Peng Liu, Yung-Hsiang Chen, Po-Ming Ku, Chia-Yang Li, Hsiu-Hua Chen, Hui-Ching Chiang, Chiao-Lin Wang, Huang-Jen Chen, Yen-Chieh Chen, and Chong-Chao Hsieh*

PLoS One. 2016 May 24; 11(5): e0156059  

MULTIDISCIPLINARY SCIENCES   IF:2.806    R/K: 15/64=23.43%

1

Anti-inflammatory Effects of Resveratrol on Hypoxia/Reoxygenation–induced Alveolar  Epithelial Cell Dysfunction. 

Liu, Po-Len; Chong, Inn-Wen; Lee, Yi-Chen; Tsai, Jong-Rung; Wang, Hui -Min; Hsieh, Chong-Chao; 
 Kuo, Hsuan -Fu; Liu, Wei-Lun; Chen, Yung-Hsiang; Chen, Hsiu-Lin

 J Agric Food Chem 2015 Oct 22(PMID:26466890)    SCI; Original articlesAGRICULTURE,

 MULTIDISCIPLINARY IF:2.912 ; 2/56=3.571%

2

Curcumin inhibits non-small cell lung cancer cells metastasis through the adiponectin /
NF- kB/ MMPs signaling pathway

Jong-Rung Tsai,Po-Len Liu, Yung -Hsiang Chen, Shah-Hwa Chou, Ming -Chan Yang, Yu-Jen Cheng,
Jhi- Jhu Hwang, and Inn-Wen Chong

PLoS One.2015 Dec 10;10(12):e0144462.     SCI;  Original articles

RESPIRATORY SYSTEM IF:7.483 ; 5/57=8.77%

3

Epigallocatechin Gallate Attenuates Proliferation and Oxidative Stress in Human Vascular Smooth Muscle Cells induced by Interlukin-1beta via Heme Oxygenase-1.
Liu PL 
, Kuo HF, Chong IW, Liu JT, Hsieh CC*
Mediators of inflammation (Manuscript number: 2014-523684 ; In Press)
(IF: 3.882; Ranking:74 /185=28.4%; Q2); Category: Cell Biology
SCI; Original articles

4

Krüppel-like Factor 5 Mediates Proinflammatory Cytokine Expression in Lipopolysaccharide-induced Acute Lung Injury through Upregulation of Nuclear Factor-kappaB Phosphorylation in Vitro and in Vivo.
Chen HL, Chong IW, Lee YC, Tsai JR, Yuan SSF, Wang HM, Liu WL, Liu PL* 
Mediators of inflammation (Manuscript number: 2014-281984 ; In Press)
(IF: 3.882; Ranking:74 /185=28.4%; Q2); Category: Cell Biology
SCI; Original articles

5



Synthesis and Characterization of Cationic Polymeric Nanoparticles as Simvastatin Carriers for Enhancing the Osteogenesis of Bone Marrow Mesenchymal Stem Cells.
Wang CZ, Fu YC, Jian SC, Wang YH, Liu PL, Ho ML, Wang CK*
J Colloid Interface Sci. 2014 Jun 22;432C:190-199. 
(IF: 3.552; Ranking: 38 /136=27.94%; Q2); Category: Chemistry
SCI; Original articles; PMID:25086394

6



Ginkgo Biloba Extract Decreases Non-Small Cell Lung Cancer Cell Migration by Downregulating Metastasis-Associated Factor Heat-Shock Protein 27.
Tsai JR, Liu PL, Chen YH, Chou SH, Yang MC, Cheng YJ, Hwang JJ, Yin WH, Chong IW*
Plos one ; 2014 Mar 11;9(3):e91331.
(IF: 3.73; Ranking:7 /57=12.5%; Q1); Category: Multidisciplinary Sciences
SCI; Original articles; PMID: 24618684

7

Cationic Nanoparticles with Quaternary Ammonium Functionalized PLGA-PEG-based Copolymers for Potent Gene Transfection.
Wang YH, Fu YC, Chiu HC, Wang CZ, Lo SP, Ho ML, Liu PL, Wang CK*
Journal of Nanoparticle Research ; Nov2013, Vol. 15 Issue 11, p1 
(IF: 2.175 ; Ranking:57 /241=23.651%; Q1); Category: Materials Science, Multidisciplinary
ISSN; Original articles; ACCESSION: 92576419

8

Biofunctional Constituents from Liriodendron Tulipifera for Antioxidants and Melanogenesis Inhibitors.
Li WJ, Lin YC, Wu PF, Wen ZH, Liu PL, Chen CY , Wang HM*
Int J Mol Sci. 2013 Jan 15;14(1):1698-712 
(IF:2.598 ; Ranking: 45/154=29.2207%; Q2); Category: Chemistry, Multidisciplinary
SCI; Original articles; PMID: 20877235

9

Antimelanoma and Antityrosinase from Alpinia galangal Constituents
Chih-Yu Lo*, Po-Len Liu*, Li-Ching Lin, Yen-Ting Chen, You-Cheng Hseu, Zhi-Hong Wen, and HuiMinWang.
The Scientific World Journal, vol. 2013, Article ID 186505 (Co-first author)
PMID:23943503 (IF: 1.73 ; Ranking:13 /56=23.214%; Q1)

10

2.Magnolol Induces Apoptosis via Caspase-Independent Pathways in Non-Small Cell Lung
Cancer 
Jong-Rung Tsai, Inn-Wen Chong, , Yung-Hsiang Chen, Wei-Hsian Yin, Chen HL , and Po-Len Liu*
Arch Pharm Res. 2013 Aug 14. 
PMID:23943503 (IF:1.538 ; Ranking:180 /260=69.2%; Q3)

11

Endothelial Progenitor Cell Dysfunction in Cardiovascular Diseases – Role of Reactive Oxygen Species and Inflammation. 
Chih-Pei Lin, Feng-Yen Lin, Po-Hsun Huang, Yuh Lien Chen, Wen-Chi Chen, Huey Y. Chen, Yu-Chuen Huang, Wen-Ling Liao, Po-Len Liu*, Yung-Hsiang Chen* and Huey-Chun Huang*.
BioMed Research International, Article ID 845037, 2013. doi:10.1155/2013/845037 (Review); (Corresponding author) (IF:2.36 ; Ranking: 65/158= 41.139%; Q2)

12

Biofunctional constituents from Liriodendron tulipifera for antioxidants and melanogenesis inhibitors
Wei-Jen Li, Yi-Chieh Lin, Pei-Fang Wu, Zhi-Hong wen, Po-Len Liu, Chung-Yi Chen , Hui-Min Wang 
Int J Mol Sci. 07 September 2012 (Accept: ISSN 1422-0067) 
(IF:2.598 ; Ranking: 45/154=29.2207%; Q2)

13

High Expression of Heme Oxygenase-1 is Associated with Tumor Invasiveness and Poor Outcomes in Non-Small Cell Lung Cancer Patients 
Jong-Rung Tsai, Hui-Min Wang , Po-Len Liu, PhD,Yung-Hsiang Chen, Ming-Chan Yang, Shah-Hwa Chou, Yu-Jen Cheng, Wei-Hsian Yin, Jhi-Jhu Hwang and Inn-Wen Chong
Cellular Oncology. 2012 Dec;35(6):461-71 
PMID:23055342 ?(IF:3.105 ; Ranking: 17/79=21.518% ; Q1)

14

Biofunctional constituents from Liriodendron tulipifera for antioxidants and melanogenesis inhibitors
Wei-Jen Li, Yi-Chieh Lin, Pei-Fang Wu, Zhi-Hong wen, Po-Len Liu, Chung-Yi Chen , Hui-Min Wang 
Int J Mol Sci. 07 September 2012 (Accept: ISSN 1422-0067)
(IF:2.598 ; Ranking: 45/154=29.2207%; Q2)

15

Biological properties of acidic cosmetic water from seawater.  
Liao WT, Huang TS, Chiu CC, Pan JL, Liang SS, Chen BH, Chen SH, Liu PL, Wang HC, Wen ZH, Wang HM, Hsiao SW.
Int J Mol Sci. 2012;13(5):5952-71. Epub 2012 May 16.
PMID:22754342 (IF:2.598 ; Ranking: 45/154=29.2207%; Q2)

16

Role of pigment epithelium-derived factor in stem/progenitor cell-associated neovascularization.  
Liu JT, Chen YL, Chen WC, Chen HY, Lin YW, Wang SH, Man KM, Wan HM, Yin WH, Liu PL*, Chen YH*.
J Biomed Biotechnol. 2012;2012:871272. Epub 2012 May 22. (Review); (Corresponding author) 
PMID:22685380 (IF:2.436 ; Ranking: 65/157=41.4012%; Q2)

17

Magnolol: A multifunctional compound isolated from the Chinese medicinal plant Magnolia officinalis.
Yung-Hsiang Chen, Po-Hsun Huang, Feng-Yen Lin, Wen-Chi Chen, Yuh-Lien Chen, Wei-Hsian Yin, Kee-Ming Man, Po-Len Liu* 

European Journal of Integrative Medicine2011; e311-e318 (Review). (Corresponding author) 
(IF= 1.2, Rank:13/21=61.904%
Q3)(NSC100-2320-B-037-009-)

18

Monascus purpureus-fermented rice inhibits tumor necrosis factor-α-induced upregulation of matrix metalloproteinase 2 and 9 in human aortic smooth muscle cells. 
Lin CP, Huang PH, Tsai HS, Wu TC, Leu HB, Liu PL , Chen YH
J Pharm Pharmacol. 2011 Dec;63(12):1587-94.
PMID:22060290(IF= 1.918, Rank:144/252=57.14%
Q3)(NSC100-2320-B-037-009-)

19

Goniothalamin inhibits growth of human lung cancer cells through DNA damage, apoptosis, and reduced migration ability.
Chiu CC, Liu PL , Huang KJ, Wang HM, Chang KF, Chou CK, Chang FR, Chong IW, Fang K, Chen JS, Chang HW, Wu YC.
J Agric Food Chem2011; 59(8):4288-93
PMID:21391609(IF= 2.816, Rank:2/55=3.63%
Q1)

20

Associations between endothelin-1 and adiponectin in chronic heart failure.
Yin WH, #Chen YH #,Wei J, Jen HL, Huang WP, Young MS, Liu PL *
Cardiology2011,118:207-216. (Corresponding author) 
PMID:21711170(IF= 1.982, Rank:58/114=50.877%
Q3)(NSC99-2320-B-350-002-MY3)

21

Inadequate energy delivery during early critical illness correlates with increased risk of mortality in patients who survive at least seven days: a retrospective study.
Tsai JR, Chang WT, Sheu CC, Wu YJ, Sheu YH, Liu PL , Ker CG, Huang MC
Clin Nutr. 2011 Apr;30(2):209-14.
PMID
20943293 (SCI ; IF= 3.41 Rinking15/ 70=21.428%Q1)(NSC97-2320-B-020-002-MY3 )

22

Intraocular pressure-lowering effect of auricular acupressure in patients with glaucoma: a prospective, single-blinded, randomized controlled trial.
Her JS, Liu PL , Cheng NC, Hung HC, Huang PH, Chen YL, Lin CP, Lee CH, Chiu CC, Yu JS, Wang HS, Lee YJ, Shen JL, Chen WC, Chen YH.
J Altern Complement Med. 2010 Nov;16(11):1177-84
PMID:2105884 (SCI, IF
1.498, Ranking: 7/21=33.33%Q2)

23

Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders. 
Shen JL, Man KM, Huang PH, Cheng YW, Liu PL* , Chou MC*, Chen YH*
Molecules. 2010;16 (9):6452-65. (Review). (Corresponding author)
PMID
20877235 (IF=1.988, Ranking: 27/56=48.214%Q2) (NSC97-2320-B-037-022-MY3)

24

Ginkgo biloba extract suppresses endotoxin-mediated monocyte activation by inhibiting nitric oxide- and tristetraprolin-mediated toll-like receptor 4 expression. 
Lee YW, Lin JA, Chang CC, Chen YH,Liu PL, Lee AW, Tsai JC, Li CY, Tsai CS, Chen TL, Lin FY. J Nutr Biochem. 2010 Jul 22.
PMID
20655717 (IF=4.538, Ranking: 67/286=23.426%Q1)(NSC97-2314-B-038-035-MY2)

25

Applications of meridian electrical conductance for renal colic: a prospective study.  
Lee CT, Chang YH, Lin WY, Xu JM, Chen HY, Chou PL, Cheng CW, Chen YL, Lin FY, Tsai FJ, Huang HL, Man KM, Liu PL , Liu JT, Chen WC, Chen YH.
J Altern Complement Med. 2010 Aug; 16(8):861-6.
PMID
20642363 (SCI, IF1.498, Ranking: 7/21=33.33%Q2)

26

Decreased Expression of Thrombomodulin is Correlated with Tumor Cell Invasiveness and Poor Prognosis in Non-small Cell Lung Cancer 
Liu PL 
, Tsai JR, Chaeles AL, Hwang JJ, Chou SH, Ping YH, Lin FY, Chen YL, Hung CY, Chen WC, Chen YH, Chong IW
Mol Carcinog. 2010, 49(10); 874-881.
PMID
20607726 (SCI ; IF= 3.265 Rinking63/ 185=34.054%Q2)(NSC96-2314-B-037-0643)

27

Resveratrol inhibits human lung adenocarcinoma cell metastasis by suppressing heme oxygenase 1-mediated nuclear factor-κB pathway and subsequently downregulating expression of matrix metalloproteinases. 
Liu PL , Tsai JR, Chaeles AL, Hwang JJ, Chou SH, Ping YH, Chen YL, Hung CY, Chen WC, Chen YH, Chong IW
Mol Nutr Food Res. 2010 Jul; 54 Suppl 2: S196-204
PMID: 20461740 (SCI ; IF=4.713, Rank: 1/128=0.7812%
Q1) (NSC97-2320-B-037-022-MY3)

28

Identification of melamine/cyanuric acid-containing nephrolithiasis by infrared spectroscopy.Chen WC, Wu SY, Liu HP, Chang CH, Chen HY, Chen HY, Tsai CH, Chang YC, Tsai FJ, Man KM, Liu PL, Lin FY, Shen JL, Lin WY, Chen YH 
J Clin Lab Anal. 2010; 24(2):92-9. 
PMID
20333762 (SCI ; IF= 0.855, Rinking20/ 29=68.96%Q3)

29

Association of interleukin-18 gene polymorphisms with calcium oxalate kidney stone disease. 
Lai KC, Lin WY, Man KM, Tsai CH, Chen HY, Tsai FJ, Chen FJ, Chen HY, Liu HP, Ho TJ, Huang PH, Liu PL , Lin FY, Liu JT, Chen YH, Chen WC
Scand J Urol Nephrol.2010 Feb; 44 (1):20-6. 
PMID
20017708 (SCI ; IF= 1.031, Rinking19/31=61.29%Q3)

30

HMGB1-Mediated MMP-9 Expression in Non-Small Cell Lung Cancer Contributes to Tumor 
Cell Invasiveness. 

Liu PLTsai JRHwang JJChou SHCheng YJLin FYChen YLHung CYChen WCChen YHChong IW
 2010, Nov; 43(5):530-8.
PMID: 19933377 (SCI, IF:5.125 ; Ranking:5/48=10.41%;Q1 ) (NSC
96-2314-B-037-064)

31

Antioxidative and hepatoprotective effects of magnolol on acetaminophen-induced liver damage in rats.  
Chen YH, Lin FY, Liu PL , Huang YT, Chiu JH, Chang YC, Man KM, Hong CY, Ho YY, Lai MT.
Arch Pharm Res. 2009 Feb;32(2):221-8. 
PMID
19280152 (SCI ; IF:1.624 ; Ranking:37/59=64.406%;Q3)

32

Tocotrienol-rich fraction of palm oil exhibits anti-inflammatory property by suppressing the expression of inflammatory mediators in human monocytic cells.
Wu SJ, Liu PL , Ng LT.
Mol Nutr Food Res. 2008 Aug;52(8):921-9. 
PMID
18481320(SCI ; IF=4.713, Rank: 1/128=0.7812%Q1) (NSC97-2313-B041-002-MY3 )

33

Cholestin (Monascus purpureus rice) inhibits homocysteine-induced reactive oxygen species generation, nuclear factor-kappaB activation, and vascular cell adhesion molecule-1 expression in human aortic endothelial cells.
Lin CP, Chen YH, Chen JW, Leu HB, Liu PL , Huang SL.? 
J Biomed Sci. 2008 Mar;15(2):183-96. 
PMID
18481320 (SCI; IF=1.962, Rank: 54/106=50.943%Q3)

34

Wood smoke extract induces oxidative tress-mediated caspase-independent apoptosis in human lung endothelial cells: role of AIF and EndoG. Am J Physiol Lung Cell Mol Physiol. 2005; 289: L739-749. (SCI. NSC 92-2320-B-010-038)

35

Adenovirus-mediated overexpression of catalase attenuates oxLDL- induced apoptosis in human aortic endothelial cells via AP-1 and c-Jun N-terminal kinase/extracellular signal-regulated kinase mitogen-activated protein kinase pathways. Lin SJ, Shyue SK, Liu PL, Chen YH, Ku HH, Chen JW, Tam KB, and Chen YL. J Mol Cell Cardiol. 2004; 36: 129-139. (IF=5.054; Rank: 38/157=24.2%) (SCI)

序號 科技部計畫名稱及編號

補助

單位

執行期限 金額

工作

性質

1

色素上皮衍生因子透過抑制癌症相關發炎反應減少癌症惡病質:臨床病人、細胞與動物的轉譯醫學研究

(105-2314-B-037 -046 -)

科技部

2016/0801~

2017/0731

1,150,000 主持人
2

脂聯素在烹調油煙引發肺纖維化的保護效果與分子機制

(105-2314-B-037 -047 -)

科技部

2016/0801~

2017/0731

1,050,000

共同

主持人

3

白藜蘆醇透過調控色素上皮衍生因子/過氧化物酶增生因子活化受體-g路徑抑制新生兒缺氧誘發的肺動脈高壓

(105-2314-B-037 -053 -)

科技部

2016/0801~

2017/0731

1,123,000

共同

主持人

4

在缺氧情境下菸鹼胺磷酸核醣基轉移酶(visfatin)可透過調控細胞自噬的表現來促進肺癌之生成與進展

(104-2314-B-037-071-MY2)

科技部

2015/0801~

2017/0731

2,200,000

共同

主持人

5 PEDF在急性心肌梗塞時調控細胞自噬與長非編碼RNA的表達(104-2314-B-037-081-MY2) 科技部

2015/0801~

2017/0731

2,200,000

共同

主持人

6 PEDF調控缺氧誘發肺癌轉移機制與長非編碼RNA的表達(104-2314-B-037-087-) 科技部

2015/0801~

2016/0731

800,000 主持人
7 HMGB1NAMPT經由細胞自噬導致非小細胞肺癌產生化療抗藥性之研究(103-2314-B-037-051-) 科技部

2014/8/1~

2015/7/31

1,100,000

共同

主持人

8 色素上皮衍生因子在非小細胞肺癌的多重抗腫瘤功效(102-2314-B-037-067-) 科技部

2012/8/1~

2013/7/31

90,000 主持人
9 HMGB1對於非小細胞肺癌之上皮-間質轉化與化療抗藥性的影響(101-2314-B-037-065-MY2) 科技部

2012/8/1~

2014/7/31

2,100,000

共同

主持人

10 脂泌素在人類非小細胞肺癌轉移之角色與薑黃素抗癌效果之探討(100-2320-B-037-012-MY2) 科技部

2011/8/1~

2013/7/31

1,900,000

共同

主持人

11

銀杏葉活性成份KaempferolQuercetinIsorhamnetinTerpene lactones對肺癌轉移的抑制效果--探討熱休克蛋白27在肺癌的表現情形與預後之相關性(N100185)

(100-2320-B-037-009)

科技部

2011/8/1~

2012/7/31

800,000 主持人
12 白藜蘆醇對心衰竭病患脂締素之影響(99-2320-B-350-002-MY3) 科技部

2010/8/1~

2013/7/31

2,700,000

共同

主持人

13

氧化酶體增生活化受體調控第一型血紅素氧化酶促進人類肺腺癌細胞侵襲與轉移機轉的研究

(99-2314-B-037-058-MY2)

科技部

2010/8/1~

2012/7/31

1,902,000

共同

主持人

14

Adiponectin/adiponectin接受體基因多型性/基因表現與飲食脂肪酸組成對糖尿病以及糖尿病腎病變之影響

(98-2314-B-037-044-MY3)

科技部

2009/8/1~

2012/7/31

3,800,000

共同

主持人

15

白藜蘆醇抑制人類肺癌細胞內第一型血基質氧化的表現降低肺癌細胞的增生與轉移

(97-2320-B-037-022-MY3)

科技部

2008/8/1~

2011/7/31

4,560,000 主持人
16 樹薯根部萃取之抗氧化及抗癌活性及其使用為運動員之能量補充品之探討(97-2320-B-020-002-MY3) 科技部

2008/8/1~

2011/7/31

2,700,000 共同主持人

研究計畫:

序號 產學計畫名稱及編號

補助

單位

執行期限 金額 工作性質
1

台灣可林氣態二氧化氯

大鼠呼吸道致敏性測試

台灣可林生化科技有限公司

2016/0801~

2017/0131

600,000 主持人
2 開發機械力擠壓裝置於生醫材料與細胞間的力學生物學應用--承洺科技

經濟部

工業局

2016/0801~

2017/0131

60,000

協同

主持人

序號 院內、 校內、基金會計畫名稱及編號

補助

單位

執行期限 金額

工作

性質

1 色素上皮衍生因子透過調控PPAR-gmiRNA 27b的表達對抗急性肺損傷 (KMUH104-4M32) 高醫院內研究計畫

2016/1/1~

2016/12/30

250,000

共同

主持人

2 色素上皮衍生因子對於缺血再灌流所引發心肌損傷的保護功效 (KMUH102-2M18) 高醫院內研究計畫

2014/1/1~

2014/12/30

200,000

共同

主持人

3 薑黃素調控HMGB1氧化減少LPS引發之急性肺損(KMUH102-2M08) 高醫院內研究計畫

2014/1/1~

2014/12/30

250,000

共同

主持人

4 探討白藜蘆醇預防新生兒缺氧再氧合所誘發的肺損傷機制 (KMUH9-9M63) 高醫院內研究計畫

2011/2/1~

2012/1/31

200,000

共同

主持人

5 探討厚朴酚(Magnolol)誘發肺癌細胞凋亡之相關路徑與機轉 (KMU-Q098022) 高醫院內研究計畫

2011/2/1~

2012/1/31

250,000

共同

主持人

6

KLF5調控脂多醣所誘發的急性肺損傷

(KMU-Q098022)

高醫院內研究計畫

2011/2/1~

2012/1/31

320,590

共同

主持人

7 HMGB1蛋白質對於木屑煙造成人類肺動脈內皮細胞損傷及黏附因子表現之影響(1-2臨床研究) (Q096025) 高醫院內研究計畫

2008/2/1~

2009/2/1

250,000

共同

主持人

8 熱休克蛋白27在銀杏萃取物抑制人類肺癌細胞增生與侵犯的角色 高醫校內新聘教師研究計畫

2010/2/10~

2010/12/31

400,000

共同

主持人

9

薑黃素透過Lin28/Let-7 路徑抑制肺癌的進展

(103CM-KMU-08)

高醫奇美研究計畫

2014/05/01~

2015/04/30

500,000 主持人
10 薑黃素透過抑制HMGB1的表現抑制非小細胞肺癌的進展(CLFHR10423) 奇美柳營院內計畫

2015/0801~

2016/0731

310,000

共同

主持人

11 色素上皮衍生因子調控細胞自噬對抗缺氧再灌流引發的心肌損傷 (KMTTH-103-010) 市立大同醫院院內計畫

2015/1/1~

2015/12/30

200,000

共同

主持人

12 紅酒多酚白藜蘆醇抑制香煙萃取物引發之肺血管損傷(Q097044) 高醫校內新聘教師研究計畫

2007/11/1~

2008/7/31

200,000 主持人
13 HMGB1蛋白質對於木屑煙造成人類肺動脈內皮細胞損傷及黏附因子表現之影響(1-1基礎研究) 高醫校內新聘教師研究計畫

2006/12/1~

2007/7/31

250,000 主持人
14 色素上皮衍生因子減少陰電性低密度膽固醇引發的血管內皮細胞功能障礙 (BC50-D10-00054) 高醫大呼吸治療學系學研究基金會

2013/05/01~

2013/08/31

350,000 主持人
15 高遷移率族蛋白B1在氧化低密度膽固醇引發的血管內皮細胞功能障礙過程中所扮演的角色 (BC50-D10-00055) 高醫大呼吸治療學系學研究基金會

2013/08/01~

2014/07/31

500,000 主持人

專利:

系統編號 專利類別 申請專利名稱 申請國家 申請日 申請號 獲證日 證書號 案件狀態
102012-US 發明 具雙影像追蹤探針之高分子奈米粒子覆合金團簇之藥物載體 美國 2015-03-19 14/662,242    

王志光、潘力誠、李之昀、林宏哲林哲緯、劉博侖、史秉修
100002-TW 發明 用於促進皮膚細胞增生及/或遷移的組成物、生薑萃取物及其醫藥組成物 中華民國 2011-11-16 100141736 2014-08-01 I446919

王惠民、陳中一、邱建志、周怡廷、劉博侖
100002-US 發明 用於促進皮膚細胞增生及/或遷移的組成物、生薑萃取物及其醫藥組成物 美國 2012-04-12 13/445,451 2014-07-08 8,772,347

王惠民、陳中一、邱建志、周怡廷、劉博侖
102012-TW 發明 具雙影像追蹤探針之高分子奈米載體及其製備方法 中華民國 2014-03-21 103110625 2016-04-21 I530296

王志光、潘力誠、李之昀、林宏哲林哲緯、劉博侖、史秉修

得獎:

年度/單位 名稱 獎助內容
99年/國科會 國科會獎勵優秀人才 彈性薪資
100年/國科會 國科會獎勵優秀人才 彈性薪資
101年/國科會 國科會獎勵優秀人才 彈性薪資
102年-科技部 科技部獎勵優秀人才 彈性薪資
102年-科技部 科技部獎勵優秀人才 彈性薪資
103年-科技部 科技部獎勵優秀人才 彈性薪資
104年-科技部 科技部獎勵優秀人才 彈性薪資
105年-科技部 科技部獎勵優秀人才 彈性薪資

審稿:

Journal Ref. No Editor-in-Chief Day
Arabian Journal of Chemistry ARABJC-D-16-00673 Dr. AbdulRahman A. Al-Warthan 20160520
INQUIRY INQ-16-0065 Dr. Wu Hsin-Hung 20160603

 

 

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